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5C research projects

Melatonin secretion during puberty - A systematic review

As part of the project "Sleep hormones in healthy children - reference material for the treatment of sleep disorders in children with CNS tumours", a systematic review on melatonin concentrations in children and adolescents has been written.

Coordinator

Supervisor / Partners

Christian Corfitz Andersen, Medical Student, Scholar

René Mathiasen, Poul Jørgen Jennum, Nanette Marinette Monique Debes

Where

Paediatric Oncology Laboratory, Rigshospitalet-Blegdamsvej.
Danish Centre for Sleep Medicine, Neurophysiology Clinic, Rigshospitalet-Glostrup.

Contact information

Visual impairment in children with primary brain tumours

The aim of the study is to investigate the diagnostic and prognostic significance of visual impairment as a symptom and/or clinical finding among paediatric patients diagnosed with brain tumours.

Coordinator

Supervisor / Partners

Caroline Sophie Kleis Schmidt, Medical Student, Scholar

Sarah Linea von Holstein, Kjeld Schmiegelow, René Mathiasen

Where

Paediatric Oncology Laboratory and Eye Clinic Rigshospitalet-Glostrup

Contact information

Regulatory mechanisms in Diffuse Infiltrating Pons Gliomas

Research field: In Vitro models (cell cultures), RNA regulation in DIPG, epigenetic regulation, screening models for drugs. Pilot studies for the establishment of Patient derived xenograft (mouse models).
Status:
1) Functional analysis of DNA damage signalling pathways and selected DNA repair pathway in paediatric H3K27M mutant and H3K27 wild-type gliomas has been performed. Further investigation of the activation of DDR with and without ionising radiation needs to be included as well as a microscopy-based quantification of foci formation to see the broader picture.
2)
A drug screening using the CNS-permeable drug library for radiosensitivity of H3K27M-mutated paediatric gliomas has been performed. This objective was split into two sub-objectives A (CNS drug screen) and B (drug validation and in vivo assessment). This has been finalised.

Coordinator

Supervisor / Partners

Henriette

René Mathiasen

Where

Denmark

Contact information

European study of cerebellar mutism syndrome (CMS) in children with posterior fossa tumors

Prospective clinical study that follows children after tumor surgery in the cerebellum, and which examines which children are affected by muteness, balance and coordination difficulties, paralysis and emotional disturbances - cerebellar mutism syndrome

Coordinator

Supervisor / Partners

Aske Foldbjerg Laustsen, doctor, PhD student

Marianne Juhler, Kjeld Schmiegelow, René Mathiasen, Astrid Marie Sehested and Jonathan Kjær Grønbæk

Where

International multicenter study based on Rigshospitalet

Contact information

The diagnostic value of 18F-FET PET/MR in CNS tumors in children and adolescents

The project seeks to clarify the diagnostic value of 18F-FET PET/MR in CNS tumors in children and adolescents, including the modality's ability to differentiate residual tumor compared to MRI

Coordinator

Supervisor / Partners

Lisbeth Marner, MD, PhD, Clinic for Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet

Astrid Sehested, Karsten Nysom, Helle Broholm, and others.

Where

Clinic for Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet

Contact information

Eye symptoms in children with brain cancer

Retrospective study of eye symptoms in children with brain tumours in the time leading up to diagnosis with the aim of earlier diagnosis

Coordinator

Supervisor / Partners

Sarah Linea von Holstein, PhD, Department Physician/post.doc Eye Clinic Rigshospitalet-Glostrup

René Mathiasen, Kamilla Nissen, Kjeld Schmiegelow,
Astrid Sehested, Peter Toft,
Steffen Heegaard

Where

Eye Clinic Rigshospitalet-Glostrup

Contact information

Regulatory mechanisms in diffusely infiltrating pons gliomas (DIPG)

Investigation of the interaction between H3K27M mutation, replication stress and the DNA damage response in DIPG

Coordinator

Supervisor / Partners

Henriette Pedersen, PhD student, biomedicine

René Mathiasen, Petra Hamerlik, Kjeld Schmiegelow, Marja Jäättelä

Where

The Danish Cancer Society, Brain Tumor Biology Group

Contact information

"Hjernetegn"

A Danish awareness campaign focusing on reducing time to diagnosis in children and adolescents with brain tumors

Coordinator

Supervisor / Partners

Kathrine Synne Weile, PhD student, 1st reserve physician in Clinical Oncology

Jeanette Falck Winther, Rene Mathiasen, Henrik Hasle and Louise Tram Henriksen

Where

Children and Young People, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University

Contact information

Late effects after childhood brain tumour treatment

Coordinator

Supervisor / Partners

Anne Sophie Lind Helligsø, Medical Doctor, PhD Student

Jeanette Falck Winther, Henrik Hasle, Louise Tram Henriksen, Line Kenborg

Where

Aarhus University - Aarhus University Hospital

Contact information

Establishment of cell lines and mouse models (patient-derived xenografts) from childhood brain tumors

Establishment of mouse models for the purpose of pre-clinical testing of drugs, among other things

Coordinator

Supervisor / Partners

Henriette Pedersen, PhD student, biomedicine

René Mathiasen, Petra Hamerlik, Kjeld Schmiegelow, Marja Jäättelä

Where

Danish Cancer Society, The Brain Tumor Biology Group

Contact information

Cerebrospinal fluid in children with CNS malignancies

The project investigates with proteo- and glycomics specific properties of the cerebrospinal fluid during oncological conditions of the central nervous system in children and adolescents. The aim of the project is to develop the concept of liquid biopsy in paediatric neuro-oncology

Coordinator

Supervisor / Partners

Christian Mirian, Medical Doctor, PhD Student

René Mathiasen, Maria Thastrup, Matilda Degn Vinther, Ole Østergaard Kjeld Schmiegelow, Jesper Olsen

Where

Paediatric Oncology Laboratory, Rigshospitalet; Neurosurgery Clinic, Rigshospitalet
Centre for Protein Research, Novo Nordisk Foundation, University of Copenhagen

Contact information

New medicine for children with cancer

Conduct trials of medicines for children and adolescents with cancer, with a special focus on diseases with no standard curative treatment

Coordinator

Supervisor / Partners

Karsten Nysom

Ruta Tuckuviene, Kjeld Schmiegelow, Henrik Hasle

Where

Rigshospitalet, Department of Paediatrics, section 5002

Contact information

Characterisation of the innate metabolome in children with CNS tumours

The project seeks to determine whether the innate metabolome in the peripheral blood of children who develop CNS tumours differs from that of healthy controls, and to what extent it can be used as a screening method or prognostic marker in a given case.

Coordinator

Supervisor / Partners

Jon Foss-Skiftresvik, 1st resident in neurosurgery, PhD Student

Madeleine Ernst, René Mathiasen

Where

Department of Congenital Diseases, Statens Serum Institut; Paediatric Oncology Laboratory, Rigshospitalet; Neurosurgery Clinic, Rigshospitalet

Contact information

Automated mapping of CNS tumours in children

Automatic mapping of CNS tumours using artificial intelligence trained with expert mapping will ease the workload for doctors and standardise the mapping process for the benefit of patients.

Coordinator

Supervisor / Partners

Claes Nøhr Ladefoged, MSc, PhD

Flemming Littrup Andersen, Lise Borgwardt, Lisbeth Marner, Ian Law

Where

Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet

Contact information

Identifying prognostic biomarkers in CNS tumours in children

Artificial intelligence for decision support in paediatric cancer patients by investigating the correlation between multi-parametric MRI and PET and diagnosis.

Coordinator

Supervisor / Partners

Claes Nøhr Ladefoged, MSc, PhD

Flemming Littrup Andersen, Lise Borgwardt, Lisbeth Marner, Ian Law

Where

Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet

Contact information

Ultra-low-dose PET studies of children

The project will use artificial intelligence to post-process PET scans taken at ultra-low dose, as these are very noisy. A lower radiation dose will minimise the risk of the scan to the child.

Coordinator

Supervisor / Partners

Michelle Fridlund, MSc, PhD Student

Claes Nøhr Ladefoged

Where

Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet

Contact information

Surgical morbidity in children with brain tumours: A study on postoperative complications of tumour resection

Coordinator

Supervisor / Partners

Kasper Aamund Henriksen

Jon Foss-Skiftesvik, René Mathiasen / Jane Skjøth-Rasmussen, Gorm Von Oettingen

Where

National

Contact information

jon.foss-skiftesvik(att)regionh.dk

Optimal treatment of hydrocephalus in children with posterior fossa tumours: external drain or endoscopic intervention?

Coordinator

Supervisor / Partners

Kasper Aamund Henriksen

Jon Foss-Skiftesvik, René Mathiasen / Jane Skjøth-Rasmussen, Gorm Von Oettingen

Where

National

Contact information

jon.foss-skiftesvik(att)regionh.dk

Sleep disorders in children with CNS tumours

Sleep disorders in children treated for brain tumours (neurobiological markers of sleep disorders)

Coordinator

Supervisor / Partners

Line Pickerin, Medical Doctor, PhD student

Where

Contact information

PET without CT for radiation dose reduction in paediatric examinations

The project will derive a synthetic CT image from the PET scan using artificial intelligence, eliminating the radiation dose associated with acquiring CT images.

Coordinator

Supervisor / Partners

Maria Montgomery, BSc student

Claes Nøhr Ladefoged, Flemming Littrup Andersen, Sune Darkner

Where

Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet and Department of Computer Science, University of Copenhagen

Contact information

Functional methods for evaluating vision in children with tumors of the central nervous system

Prospective clinical study that aims to investigate visual field and eye movements in healthy children and children with newly diagnosed CNS tumor using a new method called SONDA.

Coordinator

Supervisor / Partners

Anna Bøthun, doctor, PhD student

Miriam Kolko, Sarah Linea von Holstein, René Mathiasen, Barbara Nordhjem

Where

Eye Clinic Rigshospitalet-Glostrup

Contact information

Protein, sugar and fat burning in children and adolescents before and after cancer treatment

The project will investigate protein, fat and sugar metabolism before and after treatment in children with brain tumours. We want to elucidate the metabolic consequences of the approximately 2-year treatment period the children undergo. By knowing the changes in fat, sugar and protein metabolism and the body's hormone response, we can optimise the nutritional status and quality of life of the children both during the course of the disease and in the long term.

Coordinator

Supervisor / Partners

Marie Mostue Naume, Medical Student, PhD Student

Mette Cathrine Ørngreen, René Mathiasen, Alfred Peter Born, Christina Engel Høi-Hansen, Thomas Krag, Maja Risager Nielsen, John Vissing, Gerrit Van Hall

Where

Rigshospitalet, Copenhagen Neuromuscular centre, section 8077 and Department of Paediatric Oncology, section 5054

Contact information

Biomarkers in pediatric chemotherapy-induced peripheral neuropathy

A clinical study investigating the potential for a reliable biomarker to assess both the risk of development and the severity of chemotherapy-induced peripheral neuropathy. A task that, with current methods, is both difficult and resource-intensive.

Data collection has been completed and samples must be analyzed before data processing begins later in 2023.

Coordinator

Supervisor / Partners

Christian Bach Vase, Stud. Med., former scholar, Peter Erik Lotko Pontoppidan, Department physician, PhD, Rigshospitalet

René Mathiasen, Consultant, PhD, Rigshospitalet, Tore B. Stage, Professor, PhD, Cand.pharm, University of Southern Denmark

Where

Paediatric Oncology Research Laboratory, Rigshospitalet., Department of Health Services Research, University of Southern Denmark

Contact information

Detection of circulating tumour DNA for advanced diagnostics and treatment monitoring in children with CNS tumours

The project investigates whether detection of circulating tumour DNA in cerebrospinal fluid in children with CNS tumours can be used for diagnostics, treatment monitoring and assessment of treatment effect.

Coordinator

Supervisor / Partners

Ronja Tügel Carstensen, MD, PhD student

Torben Stamm Mikkelsen, Lars Dyrskjøt, Katja von Hoff, Britt Elmedal Laursen

Where

Children and Adolescents Aarhus University Hospital, Department of Molecular Medicine (MOMA) Aarhus University Hospital

Contact information

Platelet RNA for diagnosis and monitoring of brain tumours in children

Platelets accumulate RNA from tumours. It has been shown in adults that mapping mRNA content in platelets can map specific gene expression profiles and also identify certain genetic alterations in tumours. Thus, the method has the potential to make tumour biopsies redundant in some situations, as the molecular genetic diagnosis can be obtained from a blood sample.

For children with CNS tumours, we will map mRNA profiles in platelets in order to use it diagnostically.

Coordinator

Supervisor / Partners

Jakob Juul Sorensen, Medical Student

Mimi Kjærsgaard, Jonathan Kjær Grønbæk, Maria Rossing, René Mathiasen

Where

Department of Paediatric Oncology and Genomic Medicine

Contact information

Nystagmus as a first symptom in children with primary brain tumours

The aim of the study is to investigate the diagnostic and prognostic significance of nystagmus as a symptom and/or clinical finding in children under 18 years of age diagnosed with brain tumours.

Coordinator

Supervisor / Partners

Jacqueline Gremaud Rosenberg

Sarah Linea von Holstein, Kjeld Schmiegelow, René Mathiasen

Where

Paediatric Oncology Laboratory and Eye Clinic Rigshospitalet-Glostrup

Contact information

Growth hormone deficiency as a late effect of childhood brain tumour

A study of growth hormone deficiency as a late effect of treatment for childhood brain tumours.

Coordinator

Supervisor / Partners

Mette Marie Baunsgaard, Medical Student, Scholar

Anne Sophie Lind Helligsø, Niels Birkebæk, Henrik Hasle, Torben Stamm Mikkelsen, Louise Tram Henriksen.

Where

Children and Youth Research, Aarhus University Hospital

Contact information

Ophthalmological manifestations in children <1 year diagnosed with a CNS tumor

The aim is to investigate the ophthalmological manifestations in infants diagnosed with a CNS tumor within the first year of life in order to reduce the time from first symptom to diagnosis.

Coordinator

Supervisor / Partners

Nathali Turanzas Jensen, Stud. Med.

Sarah Linea von Holstein, René Mathiasen, Kjeld Schmiegelow

Where

Children's Oncology Laboratory and Eye Clinic, Rigshospitalet

Contact information

Nystagmus as a first symptom in children with primary brain tumours

The aim of the study is to investigate the diagnostic and prognostic significance of nystagmus as a symptom and/or clinical finding in children under 18 years of age diagnosed with brain tumours.

Coordinator

Supervisor / Partners

Jacqueline Gremaud Rosenberg, Medical Student, Scholar

Sarah Linea von Holstein, Kjeld Schmiegelow, René Mathiasen

Where

Paediatric Oncology Laboratory and Eye Clinic Rigshospitalet-Glostrup

Contact information

Early eye symptoms in children with brain tumours

Retrospective study of early eye symptoms in children with brain tumours in the time leading up to diagnosis with the aim of earlier diagnosis

Coordinator

Supervisor / Partners

Jacob Christiansen, Medical Student, Scholar

Sarah Linea von Holstein, Kjeld Schmiegelow, René Mathiasen

Where

Paediatric Oncology Research Laboratory and Eye Clinic Rigshospitalet-Glostrup

Contact information

Completed research projects

Genetic predisposition to the development of CNS tumors

The study seeks to investigate genetic predisposition for the development of CNS tumors in childhood through the use of a retrospective Danish cohort.

Coordinator

Supervisor / Partners

Jon Foss-Skiftesvik, 1st reserve doctor in neurosurgery, PhD student

Jonas Bybjerg-Grauholm, René Mathiasen, Kjeld Schmiegelow, Marianne Juhler

Where

Department of Congenital Diseases and Neonatal Genetics, Statens Serum Institut; Children's oncology laboratory, Rigshospitalet; Neurosurgery Clinic, Rigshospitalet

Contact information

jon.foss-skiftesvik(att)regionh.dk

Infection risk associated with the need for liquor drainage in children with CNS tumours

The risk of infection in paediatric patients with intracranial tumours and external ventricular drainage or ventriculoperitoneal shunt

Coordinator

Supervisor / Partners

Anna Bøthun, Medical Student, Scholar

René Mathiasen, Jane Skjøth-Rasmussen, Nadja Hawwa Vissing, Jon Foss-Skiftesvik

Where

Rigshospitalet

Contact information

Neuropsychological testing in children with CNS tumours

Neuropsychological testing of children who have had a brain tumour, as well as psychological counselling for children and relatives. Is this done to a sufficient extent

Coordinator

Supervisor / Partners

Clara Emilie Bruun, Medical Student, Scholar

René Mathiasen, Jonathan Grønkjær

Where

Rigshospitalet

Contact information

Evaluation of MRI surveillance of children with brain tumours

Follow-up regimens for brain tumours and their value. Early identification of recurrence of brain tumours

Coordinator

Supervisor / Partners

Christoffer Storm Svendsen, Medical Student, Scholar

René Mathiasen, Astrid Marie Sehested, Jonathan Grønkjær

Where

Rigshospitalet

Contact information

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